The only reason why people have to change careers to begin with is a lack of planning. Regardless of the actual reason, the root of the problem lies in mediocre planning of your career. If you're really looking to change careers, you have to plan out everything.
Start researching about your interests and your skills. What do you possess that a company would want to pay for? Maybe the music you make in your free time can be sold somewhere. Maybe the comics you make occasionally can transcend into a graphic designing career. You have to figure out two things.
1 - What skill do I have that people would pay for?
2 - Who would want to pay for the skills that I have?
Once you answer these two questions, you can easily transition into a brand new, successful career.